What question did this study set out to answer?

To determine JC virus genotypes excreted by Native American and Pacific Island populations in order to trace viral evolutionary history and prehistoric human migration.

December 23, 1997Proceedings of the National Academy of SciencesOpen Access

Asian genotypes of JC virus in Native Americans and in a Pacific Island population: Markers of viral evolution and human migration

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Authors

HAHansjürgen AgostiniUniversity of Freiburg RYRichard YanagiharaUniversity of Hawaiʻi at Mānoa VDVictor DavisUniversity of Hawaiʻi at Mānoa

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Implication

Genetic analysis reveals Asian JC virus genotypes in Native American and Pacific populations, suggesting ancient viral coevolution and migration across the Bering land bridge.

Key Points

To determine JC virus genotypes excreted by Native American and Pacific Island populations in order to trace viral evolutionary history and prehistoric human migration.
Analyzed urine samples from 68 Navaho (New Mexico), 25 Flathead (Montana), and 29 Chamorro (Guam) individuals (total N=122).
Amplified a VP1 gene fragment using PCR and determined viral genotypes and subtypes by cycle sequencing.
JC virus DNA was detected in the urine of 45/68 (66%) Navaho, 14/25 (56%) Flathead, and 20/29 (69%) Chamorro individuals.
Isolates were predominantly Asian type 2 rather than European type 1, with the East Asian subtype 2A accounting for 56% to 89% of excreted strains.
The shared viral lineage indicates infection predates European contact and human migration across the Bering land bridge, suggesting human-virus coevolution dating back 50,000 to 100,000 years.

Cite This Study

Agostini et al. (1997) studied this question.

synapsesocial.com/papers/6a6cdbca35aa2c282cdfb414 https://doi.org/10.1073/pnas.94.26.14542

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Implication

Genetic analysis reveals Asian JC virus genotypes in Native American and Pacific populations, suggesting ancient viral coevolution and migration across the Bering land bridge.

Asian genotypes of JC virus in Native Americans and in a Pacific Island population: Markers of viral evolution and human migration

Discussion

Member takes

Implication

Key Points

Cite This Study

Asian genotypes of JC virus in Native Americans and in a Pacific Island population: Markers of viral evolution and human migration

Discussion

Member takes

Implication

Key Points

Cite This Study

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