Key result
The updated computational methodology efficiently identified drug-induced changes and quantified IC50 values for five drugs in line with published values, enabling prediction of adult cardiomyocyte responses.
Why the study?
The usefulness of hiPSC-CMs for drug screening is limited by their electrophysiological immaturity compared to native adult human cardiomyocytes.
Population
Stem cell-derived cardiac microtissues (hiPSC-CMs)
Comparison
Dose escalation measurements of five drugs with known effects
Design
Preclinical computational modeling and validation study
Authors
Loading...
May refine hiPSC-CM drug screening; leaves open clinical translation pending adult cardiomyocyte validation.
An updated computational model successfully maps drug-induced electrophysiological changes from immature hiPSC-CMs to adult human cardiomyocyte phenotypes, potentially improving preclinical drug screening.
Jæger et al. (2020) studied Drug response in cardiomyocytes. Updated computational methodology (continuation-based optimization and AP model) was evaluated on Identification of drug-induced changes and IC50 quantification. The updated computational methodology efficiently identified drug-induced changes and quantified IC50 values for five drugs in line with published values, enabling prediction of adult cardiomyocyte responses.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: