Key result
Extracellular magnesium directly suppresses HERG potassium channels, suggesting its efficacy in terminating torsades de pointes is not mediated by reversing HERG inhibition.
Population
HERG potassium channels expressed in Xenopus oocytes and a human cell line (tsA201 cells)
Design
Preclinical
Authors
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Magnesium does not modulate HERG to suppress torsades; leaves open alternative mechanisms for targeted study.
Extracellular magnesium suppresses HERG potassium currents and does not reverse quinidine-induced inhibition, suggesting its clinical efficacy in terminating torsades de pointes is not mediated via HERG channel modulation.
Po et al. (1999) studied Torsades de pointes and Long QT syndrome. Extracellular magnesium and quinidine was evaluated on HERG potassium current suppression. Extracellular magnesium directly suppresses HERG potassium channels, suggesting its efficacy in terminating torsades de pointes is not mediated by reversing HERG inhibition.
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