Key result
VTE prophylaxis in breast cancer surgery significantly increased the incidence of haematoma compared to no prophylaxis (6.85% vs 3.11%, p=0.001), without reducing VTE events.
Why the study?
Routine use of venous thromboembolism prophylaxis in breast cancer surgery has caused substantial polarity among surgeons globally.
Does VTE prophylaxis prevent VTE events or increase the risk of haematoma in patients undergoing breast cancer surgery?
Population
2470 patients from 6 studies undergoing breast cancer surgery
Comparison
VTE prophylaxis vs no prophylaxis
Design
Systematic review and meta-analysis of comparative studies
Authors
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Supports avoiding routine VTE prophylaxis in breast cancer surgery; challenges perioperative guidelines and prompts reevaluation.
Meta-Analysis (n=2,470)
Does VTE prophylaxis prevent VTE events or increase the risk of haematoma in patients undergoing breast cancer surgery?
Absolute Event Rate: 6.85% vs 3.11%
p-value: p=0.001
Routine VTE prophylaxis in breast cancer surgery increases the risk of postoperative haematomas requiring surgical intervention without providing significant benefit in preventing VTE events.
Dhannoon et al. (2025) conducted a meta-analysis in breast cancer surgery (n=2,470). VTE prophylaxis vs. no prophylaxis was evaluated on incidence of haematoma (p=0.001). VTE prophylaxis in breast cancer surgery significantly increased the incidence of haematoma compared to no prophylaxis (6.85% vs 3.11%, p=0.001), without reducing VTE events.
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