What question did this study set out to answer?

To determine whether combining rehabilitative exercise training with oxandrolone and propranolol enhances muscle mass, functional capacity, and protein turnover in severely burned children.

October 17, 2017Medicine & Science in Sports & ExerciseOpen Access

Propranolol and Oxandrolone Therapy Accelerated Muscle Recovery in Burned Children

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To determine whether combining rehabilitative exercise training with oxandrolone and propranolol enhances muscle mass, functional capacity, and protein turnover in severely burned children.
Randomized, placebo-controlled trial evaluating 42 pediatric patients (aged 7–17 years) with severe burns covering over 30% of total body surface area.
Participants were randomized to receive oxandrolone plus propranolol (Oxprop; n=20) or placebo (control; n=22) starting within 96 hours of hospital admission.
All patients underwent rehabilitative exercise training (RET) beginning at discharge, with muscle strength, power, peak oxygen uptake (V˙O2peak), and protein synthesis and breakdown rates assessed pre- and post-RET.
Rehabilitative exercise training increased muscle strength, muscle power, lean body mass, and V˙O2peak in both the Oxprop and placebo groups (P < 0.01).
Increases in muscle strength and power were significantly greater with Oxprop compared with placebo (P < 0.01), leading to superior post-RET strength and power (P < 0.05).
Protein fractional synthetic rate was significantly higher with Oxprop than placebo post-RET (P < 0.01), resulting in a significantly improved net protein balance (P < 0.05).

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Implication

Randomized trial shows propranolol and oxandrolone enhance muscle recovery in severely burned children, indicating combined drug therapy boosts the benefits of rehabilitative exercise.

Cite This Study

Chao et al. (2017) studied this question.

synapsesocial.com/papers/6a6cebd1f44fa9f079db7243 https://doi.org/10.1249/mss.0000000000001459

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Implication

Randomized trial shows propranolol and oxandrolone enhance muscle recovery in severely burned children, indicating combined drug therapy boosts the benefits of rehabilitative exercise.

Propranolol and Oxandrolone Therapy Accelerated Muscle Recovery in Burned Children

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Discussion

Implication

Cite This Study

Propranolol and Oxandrolone Therapy Accelerated Muscle Recovery in Burned Children

Key Points

Discussion

Implication

Cite This Study

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