When transplantable mouse sarcomas were infected experimentally with Cl. histolyticum, and the infection controlled by systemic injections of histolyticus antitoxin, the life span of some of the animals was prolonged for as long as 20 days beyond that of the non-infected tumor bearers. But in no instance did the infection completely destroy the tumor tissue. All surviving mice, treated eventually with penicillin in order to eradicate residual infection, developed large sarcomas. Under similar conditions, no such temporary regression was observed for transplantable mouse carcinomas.
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Parker et al. (1947) studied this question.