What question did this study set out to answer?

To determine the role of macrophage scavenger receptor type A in acquired host immunity and protection against lipopolysaccharide-induced endotoxic shock.

November 3, 1997The Journal of Experimental MedicineOpen Access

The Macrophage Scavenger Receptor Type A Is Expressed by Activated Macrophages and Protects the Host Against Lethal Endotoxic Shock

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Authors

RHRichard HaworthUniversity of Hertfordshire NPNick PlattUniversity of Oxford SKSatish KeshavJohn Radcliffe Hospital

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Implication

Experimental murine study demonstrates that scavenger receptor type A protects against lethal endotoxic shock, suggesting its therapeutic potential in clearing endotoxins and dampening inflammation.

Key Points

To determine the role of macrophage scavenger receptor type A in acquired host immunity and protection against lipopolysaccharide-induced endotoxic shock.
Inoculated wild-type and scavenger receptor type A knockout (SRKO) mice with viable bacillus Calmette Guérin (BCG) to assess macrophage activation, recruitment, and bacterial restriction.
Challenged infected mice with lipopolysaccharide (LPS) to measure cytokine responses (TNF-alpha and interleukin-6) and survival, including treatment with a neutralizing anti-TNF-alpha antibody.
BCG-infected SRKO mice successfully recruited activated macrophages to granulomas and restricted bacterial replication similarly to wild-type mice.
SR-A-deficient mice showed heightened susceptibility to lethal endotoxic shock and produced markedly higher levels of TNF-alpha and interleukin-6 in response to LPS.
Treatment with an anti-TNF-alpha neutralizing antibody reduced LPS-induced mortality in SR-A-deficient mice.

Cite This Study

Haworth et al. (1997) studied this question.

synapsesocial.com/papers/6a6cf0ffa7fbea1e44078e65 https://doi.org/10.1084/jem.186.9.1431

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Implication

Experimental murine study demonstrates that scavenger receptor type A protects against lethal endotoxic shock, suggesting its therapeutic potential in clearing endotoxins and dampening inflammation.

The Macrophage Scavenger Receptor Type A Is Expressed by Activated Macrophages and Protects the Host Against Lethal Endotoxic Shock

Discussion

Member takes

Implication

Key Points

Cite This Study

The Macrophage Scavenger Receptor Type A Is Expressed by Activated Macrophages and Protects the Host Against Lethal Endotoxic Shock

Discussion

Member takes

Implication

Key Points

Cite This Study

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