Key result
Human pluripotent stem cell-derived cardiomyocyte sheets can generate reentrant arrhythmias that are terminated by anti-arrhythmic drugs, providing a model for drug screening.
Population
Human pluripotent stem cell (hPSC)-derived cardiomyocytes re-plated into cell sheets
Design
Preclinical
Authors
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This model may advance mechanistic arrhythmia research; leaves open clinical translation pending validation.
Human pluripotent stem cell-derived cardiomyocyte sheets can successfully model reentrant arrhythmias, providing a valuable platform for screening anti-arrhythmic drugs.
Kadota et al. (2012) studied Reentrant arrhythmia. Anti-arrhythmic drugs (nifekalant, E-4031, sotalol, quinidine) was evaluated on Termination of spiral waves and size of unexcitable cores. Human pluripotent stem cell-derived cardiomyocyte sheets can generate reentrant arrhythmias that are terminated by anti-arrhythmic drugs, providing a model for drug screening.
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