Key result
Calpain system dysregulation is linked to lipid disorders, inflammation, and apoptosis in vascular diseases.
Literature review reveals calpain dysregulation drives vascular injury through inflammation and apoptosis, highlighting calpain inhibition as a potential therapeutic approach.
Calpain, a key member of the Calpain cysteine protease superfamily, performs limited protein hydrolysis in a calcium-dependent manner. Its activity is tightly regulated due to the potential for non-specific cleavage of various intracellular proteins upon aberrant activation. A thorough review of the literature from 2010 to 2023 reveals 121 references discussing cardiovascular and cerebrovascular diseases. Dysregulation of the Calpain system is associated with various pathological phenomena, including lipid metabolism disorders, inflammation, apoptosis, and excitotoxicity. Although recent studies have revealed the significant role of Calpain in cardiovascular and cerebrovascular diseases, the precise mechanisms remain incompletely understood. Exploring the potential of Calpain inhibition as a therapeutic approach for the treatment of cardiovascular and cerebrovascular diseases may emerge as a compelling area of interest for future calpain research.
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Zhang et al. (2024) conducted a review in Cardiovascular and cerebrovascular diseases. Calpain system dysregulation was evaluated. Dysregulation of the Calpain system is associated with lipid metabolism disorders, inflammation, apoptosis, and excitotoxicity in cardiovascular and cerebrovascular diseases.
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