Why the study?
Does calpain mediate Angiotensin II/AT1R-induced endothelial dysfunction in preclinical models?
Does calpain mediate Angiotensin II/AT1R-induced endothelial dysfunction in preclinical models?
Calpain plays a mechanistic role in Angiotensin II-induced endothelial dysfunction, establishing it as a novel molecular target for vascular protection.
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Supports calpain inhibition for endothelial protection in Ang II models; leaves open human translation.
Scalia et al. (2011) studied this question.
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