Population
Human myocardium (diseased and normal) and rat cardiomyocytes
Comparison
Angiotensin II stimulation and calpain inhibition vs Unstimulated cardiomyocytes or normal human…
Design
Preclinical
Authors
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Preclinical Ang II-calpain-CnA pathway may promote hypertrophy; leaves open relevance to human HF.
Angiotensin II-induced calpain activation leads to targeted proteolysis of the calcineurin autoinhibitory domain, resulting in sustained calcineurin activation and nuclear translocation associated with myocardial hypertrophy.
Burkard et al. (2005) studied this question.
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