Key result
Cardiac hypertrophy in HOCM and AS without heart failure is characterized by a significant increase in calcineurin activity compared with normal hearts.
Population
Human myocardial tissue from patients with hypertrophic obstructive cardiomyopathy and aortic stenosis…
Design
Other
Authors
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Hypothesis-generating for calcineurin inhibition in HOCM and AS; requires prospective validation before clinical consideration.
Observational
Calcineurin activity is significantly increased in human cardiac hypertrophy (HOCM and AS) without heart failure, suggesting its involvement in the pathogenesis of hypertrophy.
Ritter et al. (2002) conducted an observational in Cardiac hypertrophy (Hypertrophic obstructive cardiomyopathy and aortic stenosis). Cardiac hypertrophy (HOCM and AS) vs. Normal hearts was evaluated on Calcineurin activity and protein expression. Cardiac hypertrophy in HOCM and AS without heart failure is characterized by a significant increase in calcineurin activity compared with normal hearts.
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