Why the study?
Does leukocyte calpain deficiency reduce Angiotensin II-induced atherosclerosis and abdominal aortic aneurysms in hypercholesterolemic mice?
Does leukocyte calpain deficiency reduce Angiotensin II-induced atherosclerosis and abdominal aortic aneurysms in hypercholesterolemic mice?
Leukocyte-derived calpains play a pivotal role in mediating Angiotensin II-induced atherosclerosis by influencing macrophage function, suggesting a potential therapeutic target for atherosclerosis but not abdominal aortic aneurysms.
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May attenuate Ang II-induced atherosclerosis via leukocyte calpain; leaves open aneurysm effects and human translation.
Howatt et al. (2016) studied this question.
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