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May 4, 2012Arteriosclerosis Thrombosis and Vascular BiologyOpen Access

Macrophage-Derived Angiopoietin-Like Protein 2 Accelerates Development of Abdominal Aortic Aneurysm

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Key result

Angptl2 deficiency in a mouse model decreased abdominal aortic aneurysm development, reducing aneurysmal size and expression of proinflammatory cytokines and matrix metalloproteinase-9.

Why the study?

Does Angptl2 deficiency prevent abdominal aortic aneurysm development in a CaCl2-induced mouse model?

Population

Patients with abdominal aortic aneurysm and a CaCl-induced AAA mouse model

Comparison

Angptl2 deficiency and Angptl2-deficient bone… vs Wild-type mice

Design

Preclinical

Authors

HTHirokazu TazumeKumamoto University HospitalKMKeishi MiyataKumamoto UniversityZTZhe TianHainan Normal University

Discussion

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Implication

Angptl2 inhibition merits preclinical AAA study; leaves open human translation from this mouse model.

Structured PICO

Does Angptl2 deficiency prevent abdominal aortic aneurysm development in a CaCl2-induced mouse model?

P
Population
Patients with abdominal aortic aneurysm (tissue samples) and a CaCl(2)-induced AAA mouse model (wild-type and Angptl2-deficient mice)
E
Exposure
Angptl2 deficiency (genetic knockout) and Angptl2-deficient bone marrow transplantation
C
Comparator
Wild-type mice
O
Outcome
Abdominal aortic aneurysm development (aneurysmal size, destruction of vessel structure, expression of proinflammatory cytokines and matrix metalloproteinase-9)surrogate

Macrophage-derived Angptl2 promotes abdominal aortic aneurysm development via inflammation and extracellular matrix degradation, highlighting a potential novel therapeutic target.

Cite This Study

Tazume et al. (2012) studied Abdominal aortic aneurysm. Angptl2 deficiency vs. Wild-type was evaluated on AAA development. Angptl2 deficiency in a mouse model decreased abdominal aortic aneurysm development, reducing aneurysmal size and expression of proinflammatory cytokines and matrix metalloproteinase-9.

synapsesocial.com/papers/6a94698ca0ae96a16adf37c8https://doi.org/10.1161/atvbaha.112.247866
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiopoietin-like Protein 2 Is an Important Facilitator of Inflammatory Carcinogenesis and Metastasis2011 · 132 citations
  2. 2Epidemiology and potential for prevention of abdominal aortic aneurysm1998 · 192 citations
  3. 3Synergistic upregulation of metalloproteinase‐9 by growth factors and inflammatory cytokines: an absolute requirement for transcription factor NF‐κB1998 · 514 citations
  4. 4Two-Year Outcomes after Conventional or Endovascular Repair of Abdominal Aortic Aneurysms2005 · 963 citations