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This is a Experimental Study study.

October 18, 2025FASEB BioAdvancesOpen Access

Adipocyte Calpain‐2 Deficiency Reduces Obesity‐Accelerated Abdominal Aortic Aneurysm Formation in Mice

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Calpain-2 deficiency significantly suppresses abdominal aortic aneurysm formation in obese mice, indicating a protective role against AAA development.
Adipocyte-specific depletion of calpain-2 reduces incidence of abdominal aortic aneurysms by limiting inflammation and tissue damage.
Calpain-2 inhibition prevents adverse changes in aortic structure induced by angiotensin II in diet-induced obesity models.
These findings highlight the importance of targeting adipocyte-specific calpain-2 in strategies to mitigate abdominal aortic aneurysm risk.

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Implication

Using genetically modified mice, this analysis finds calpain-2 deficiency reduces abdominal aortic aneurysm in obesity, suggesting a critical role of this protease in AAA development.

Cite This Study

Frony et al. (2025) studied this question.

synapsesocial.com/papers/68f3d0c11cb4135751d12b88 https://doi.org/10.1096/fba.2025-00202

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Implication

Using genetically modified mice, this analysis finds calpain-2 deficiency reduces abdominal aortic aneurysm in obesity, suggesting a critical role of this protease in AAA development.

Adipocyte Calpain‐2 Deficiency Reduces Obesity‐Accelerated Abdominal Aortic Aneurysm Formation in Mice

Key Points

Discussion

Implication

Cite This Study

Adipocyte Calpain‐2 Deficiency Reduces Obesity‐Accelerated Abdominal Aortic Aneurysm Formation in Mice

Key Points

Discussion

Implication

Cite This Study

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