Key result
The electrolytic inferior vena cava model produced a consistent, non-occlusive thrombus that resolved over 14 days, with thrombus weight positively correlating with sP-sel (r=0.48, p<0.0002).
The electrolytic inferior vena cava model produces a consistent, non-occlusive thrombus with constant blood flow, enabling the study of acute and chronic venous thrombosis and resolution in mice.
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Enables chronic VT thrombus resolution studies in mice; leaves open clinical translation.
Alvarado et al. (2013) studied Venous thrombosis (n=191). Electrolytic inferior vena cava model (EIM) was evaluated on Thrombus size and resolution. The electrolytic inferior vena cava model produced a consistent, non-occlusive thrombus that resolved over 14 days, with thrombus weight positively correlating with sP-sel (r=0.48, p<0.0002).
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