Key result
Multimodality imaging confirms hibernating myocardium with reduced strain and preserved viability in chronic LAD occlusion.
This preclinical study provides a multimodality imaging framework describing the morphologic and functional progression of hibernating myocardium in chronic ischemic cardiomyopathy.
Preclinical data should not alter clinical protocols; leaves open human validation of multimodality imaging for hibernating myocardium.
Although ischemic cardiomyopathy is commonly caused by chronic obstructive coronary disease, the mechanism of the cause is still under investigation. We present echocardiographic strain, magnetic resonance, and histology findings in a chronic ischemia model in preclinical study. This case illustrates the features of multimodality imaging in chronic obstructive coronary disease and gives us great insight into understanding the mechanism of ischemic cardiomyopathy.
No takes yet. Share an insight, caveat, or question.
Ishikawa et al. (2010) studied Chronic obstructive coronary disease / Ischemic cardiomyopathy (n=1). Chronic LAD occlusion via customized occluder was evaluated on Multimodality imaging features (echocardiography, MRI, histology) of hibernating myocardium. Multimodality imaging in a porcine model of chronic LAD occlusion demonstrated hibernating myocardium features, including decreased strain, subendocardial edema, and preserved viability.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: