Key result
Induced chronic severe mitral regurgitation in dogs resulted in decreased LV dP/dt (p<0.01) and reduced intrinsic contractile function despite a preserved ejection fraction.
p-value: p=<0.01
In a canine model, chronic severe mitral regurgitation with preserved ejection fraction causes significant load-independent intrinsic contractile dysfunction driven by defective calcium cycling.
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Myocyte contractile defects underlie impaired reserve in chronic MR; hypothesis-generating and requires human validation before any clinical consideration.
McGinley et al. (2007) studied chronic mitral valve regurgitation (MR) (n=14). Induced chronic mitral valve regurgitation vs. Control dogs was evaluated on LV dP/dt (p=<0.01). Induced chronic severe mitral regurgitation in dogs resulted in decreased LV dP/dt (p<0.01) and reduced intrinsic contractile function despite a preserved ejection fraction.
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