Local and Locoregional Disease Free Survival in Patients Receiving NSM or SSM Compared with Conventional Mastectomy

Introduction: In this study we evaluated local recurrence-free survival (LRFS) and locoregional recurrence-free survival (LRRFS) for women at our institution who received NSM and SSM as compared to patients receiving traditional non-skin or nipple sparing mastectomies (TM).Methods: From 2005 to 2014, women with T1-2, N0, M0 disease who did not receive radiation were included in the analysis. Patients were separated into one of three cohorts based on mastectomy type. Kaplan Meier survival estimates were used to estimate LRFS and LRRFS. Cox proportional hazards analysis was used to calculate risk factors contributing to these outcomes.Results: At eight years, LRFS was 95.9% for TM, 100.0% for NSM and 96.8% for SSM. Log-rank analysis showed no significant difference in LRFS between the 3 groups (p = 0.67). At eight years LRRFS was 94.3% for TM, 92.6% for NSM and91.4% for SSM with no significant differences seen among these groups (p = 0.51). In univariate analyses, only T-stage was a significant risk factor for local recurrence (HR 3.84, 95% CI 1.17 - 12.6, p = 0.03).Conclusions: For this patient population, SSM and NSM appear to be safe and equivalent to TM at 8 years of follow up.