Key result
Transgenic mice overexpressing TNF-alpha developed reentrant ventricular arrhythmias in 92.3% (12 of 13) of hearts compared to 0% in controls, driven by abnormal calcium handling.
Population
Transgenic mice overexpressing tumor necrosis factor-alpha in the heart and nontransgenic littermate controls
Comparison
Optical mapping of voltage and Ca in isolated… vs Nontransgenic littermate control hearts; normal…
Design
Preclinical
Authors
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TNF-α overexpression induces HF and reentrant arrhythmias in mice; hypothesis-generating for inflammation in human HF, requires validation.
Absolute Event Rate: 92.3% vs 0%
In a TNF-alpha transgenic mouse model of heart failure, action potential prolongation and abnormal calcium handling contribute to the initiation of reentrant arrhythmias.
London et al. (2003) studied Heart failure and arrhythmias. TNF-alpha overexpression vs. Nontransgenic littermates was evaluated on Reentrant ventricular arrhythmias elicited by programmed stimulation. Transgenic mice overexpressing TNF-alpha developed reentrant ventricular arrhythmias in 92.3% (12 of 13) of hearts compared to 0% in controls, driven by abnormal calcium handling.
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