March 1, 1992Cardiovascular Research
Functional implications of spontaneous sarcoplasmic reticulum Ca2+ release in the heart
Population
Myocardial tissue and cardiac cells (theoretical/review context)
Design
Review
Authors
Discussion
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Implication
S-CaOs may unify mechanisms of systolic impairment, diastolic tone, and arrhythmogenesis in HF; hypothesis-generating pending targeted clinical trials.
Structured PICO
P
Population
Myocardial tissue and cardiac cells (theoretical/review context)
Spontaneous sarcoplasmic reticulum calcium oscillations may represent a unifying cellular mechanism for the impaired systolic performance, increased diastolic tone, and arrhythmogenesis seen in heart failure.
Cite This Study
Edward G. Lakatta (1992) studied this question.