Spontaneous calcium release from the sarcoplasmic reticulum in myocardial cells: mechanisms and consequences
Population
Cardiac myocytes (isolated and in intact tissue)
Design
Review
Authors
Discussion
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Member takes
Implication
May guide arrhythmia research targeting SR Ca2+ release; leaves open clinical translation pending targeted trials.
Structured PICO
P
Population
Cardiac myocytes (isolated and in intact tissue)
Spontaneous calcium release from the sarcoplasmic reticulum is a fundamental cellular mechanism that can trigger arrhythmias and contribute to both systolic and diastolic myocardial dysfunction.
Cite This Study
Stern et al. (1988) studied this question.