Experimental study demonstrates efficient carbon-heteroatom reductive elimination from monoaryl palladium(IV) complexes in water, suggesting viable pathways for aqueous organometallic catalysis.
Monohydrocarbyl palladium(IV) complexes bearing OH, OH(2), Br, and Cl ligands at the metal and supported by facially chelating 1-hydroxy-1,1-bis(2-pyridyl)methoxide were readily prepared in water at 0 °C. These complexes reductively eliminate Ar-X (X = OH, Br, Cl) in water at room temperature in high yield, and the corresponding first-order rate constants k(OH), k(Cl), and k(Br) are on the same order of magnitude.
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Oloo et al. (2010) studied this question.
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