Key result
High concentrations of free fatty acids caused pancreatic cell damage, and caerulein induced more severe pancreatic inflammation in LPL-deficient mice compared to wild-type mice.
Population
Isolated mouse pancreatic acinar cells and lipoprotein lipase (LPL)-deficient and wild type mice
Comparison
Addition of free fatty acids, chylomicrons… vs Wild type mice or baseline/control conditions
Design
Preclinical
Authors
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May implicate FFA toxicity in HTG pancreatitis; hypothesis-generating for human LPL deficiency.
High concentrations of free fatty acids lead to pancreatic cell damage, while pancreatic lipase may counteract cell injury by preventing Ca2+ overload.
Yang et al. (2008) studied Pancreatitis. Free fatty acids and LPL deficiency vs. Wild type mice / normal conditions was evaluated on Pancreatic cell damage and inflammation. High concentrations of free fatty acids caused pancreatic cell damage, and caerulein induced more severe pancreatic inflammation in LPL-deficient mice compared to wild-type mice.
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