What question did this study set out to answer?

To identify and characterize a novel granulocyte-specific antigen targeted by autoantibodies in patients with autoimmune neutrophil granulocytopenia.

January 9, 1978Vox Sanguinis

ND1 a New Neutrophil Granulocyte Antigen

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Pedigree and serological analysis reveals a novel neutrophil antigen in autoimmune granulocytopenia patients, indicating high population prevalence.

To identify and characterize a novel granulocyte-specific antigen targeted by autoantibodies in patients with autoimmune neutrophil granulocytopenia.
Examined autoantibodies in serum samples collected from 2 patients with autoimmune neutrophil granulocytopenia.
Performed genetic linkage and segregation analysis across a four-generation family to test correlation with established neutrophil antigens NA1, NA2, NB1, NC1, and 9a.
Assessed antigen and gene frequencies within a cohort from the Dutch population (n = 67).
Identified a novel granulocyte-specific antigen, designated ND1, which is genetically independent of previously characterized antigens NA1, NA2, NB1, NC1, and 9a.
Demonstrated an ND1 antigen phenotypic frequency of 98.5% in the Dutch population (n = 67), corresponding to an estimated gene frequency of 0.88.

Verheugt et al. (1978) studied this question.

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Pedigree and serological analysis reveals a novel neutrophil antigen in autoimmune granulocytopenia patients, indicating high population prevalence.