March 12, 2006Catheterization and Cardiovascular Interventions
The relationship of obesity to ischemic outcomes following coronary stent placement in contemporary practice
Key result
Extreme obesity (BMI >32) was associated with a significantly higher rate of 6-month target vessel revascularization following PCI compared to lower BMI categories (11.3% vs 8.5%, P=0.007).
Why the study?
Does obesity affect ischemic outcomes and bleeding in patients undergoing coronary stent placement with GP IIb/IIIa inhibitors?
Population
Patients undergoing planned coronary stent placement with routine use of glycoprotein IIb/IIIa inhibitors
Comparison
Obesity, extreme obesity, or morbid obesity vs Nonobese patients
Design
Cohort
Follow-up
6 months
Authors
Discussion
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Implication
Extreme obesity was associated with higher TVR post-stenting; leaves open whether BMI-targeted strategies improve outcomes in younger patients.
Study Design
Type
Cohort
Multicenter
Yes
Structured PICO
Does obesity affect ischemic outcomes and bleeding in patients undergoing coronary stent placement with GP IIb/IIIa inhibitors?
P
Population
Patients undergoing planned coronary stent placement in the TARGET trial, evaluated for the relationship between body mass index and 6-month ischemic outcomes.
E
Exposure
Obesity (BMI > 30), extreme obesity (BMI > 32), or morbid obesity (BMI > 35)
C
Comparator
Nonobese patients
O
Outcome
30-day ischemic event rate, major bleeding, and 6-month target vessel revascularization (TVR), death, and myocardial infarctionhard clinical
Main Result
Absolute Event Rate: 11.3% vs 8.5%
p-value: p=0.007
Extreme obesity is associated with increased 6-month target vessel revascularization following coronary stenting, though obesity overall is associated with less major bleeding.
Cite This Study
Martin et al. (2006) conducted a cohort in Coronary artery disease requiring stent placement. Extreme obesity (BMI > 32) vs. Non-extremely obese patients was evaluated on 6-month target vessel revascularization (TVR) (p=0.007). Extreme obesity (BMI >32) was associated with a significantly higher rate of 6-month target vessel revascularization following PCI compared to lower BMI categories (11.3% vs 8.5%, P=0.007).