Key result
Gestational age was significantly and positively correlated with total intraventricular pressure difference in both the right (r = 0.800) and left (r = 0.818) fetal ventricles.
Why the study?
Intraventricular pressure difference is a useful marker for diastolic function, but normative data throughout gestation in normal fetuses were needed.
Observational (n=137)
Effect estimate: r = 0.800 (RV), r = 0.818 (LV)
p-value: p=<0.001
Total and segmental fetal intraventricular pressure differences increase linearly with gestational age, establishing normative data for fetal echocardiography.
Normative fetal IVPD equations now available; leaves open prospective validation before clinical adoption in diastolic assessment.
AIM: The intraventricular pressure difference (IVPD) is the pressure difference in early diastole from the base to the apex of the ventricle. It is a useful marker for evaluating diastolic function because of its role as a suction force. This study investigated the changes in total and segmental IVPDs in normal fetuses throughout gestation to obtain normative data equations. METHODS: One hundred thirty-seven healthy pregnant women at 12-40 weeks of gestation were prospectively enrolled to evaluate IVPD. The color M mode was performed, and the image was evaluated using our own code to calculate the IVPD. Segmental IVPD was divided into mid to apex and base. Pearson's correlation coefficient was used to evaluate this relationship. RESULTS: There was a significant, positive relationship between IVPD and gestational age in both ventricles (right ventricle [RV]: r = 0.800, left ventricle [LV]: r = 0.818). As for segmental IVPD, basal and mid-apical IVPD also increased with gestation in both ventricles (RV: basal, r = 0.627; mid-apical, r = 0.705; LV: basal r = 0.758; mid-apical, r = 0.756). IVPG, which was calculated as IVPD/ventricular length, also showed a weak, positive relationship with gestation in both ventricles (RV r = 0.351, p < 0.001; LV r = 0.373, p < 0.001). CONCLUSION: The total and segmental IVPDs significantly increased linearly through time.
No takes yet. Share an insight, caveat, or question.
Yamamoto et al. (2023) conducted an observational in Normal fetuses (n=137). Gestational age was evaluated on Intraventricular pressure difference (IVPD) (r = 0.800 (RV), r = 0.818 (LV), p=<0.001). Gestational age was significantly and positively correlated with total intraventricular pressure difference in both the right (r = 0.800) and left (r = 0.818) fetal ventricles.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: