The TyG index showed a stronger association with diabetes than HOMA-IR in normal-weight individuals, increasing the likelihood of diabetes by 2.37 times in males and 2.25 times in females.
Cross-Sectional (n=10,471)
Is the TyG index more strongly associated with diabetes than HOMA-IR in Korean individuals without underweight or obesity?
The TyG index is a stronger and more reliable indicator for diabetes risk than HOMA-IR in normal-weight Korean individuals.
Effect estimate: 2.370 (males) and 2.249 (females) times more likely
Background: There are higher numbers of Asian individuals with metabolically obese, normal weight (MONW) who are susceptible to diabetes than other ethnic groups. The homeostatic model assessment for insulin resistance (HOMA-IR) has been used for years to evaluate IR; however, the triglyceride-glucose (TyG) index has been highlighted as a reliable and cost-effective insulin resistance indicator. Thus, this study explored the association of the HOMA-IR versus the TyG index with diabetes in individuals without underweight or obesity. Methods: This cross-sectional study included 10,471 Korean individuals whose body mass index was ≥18.5 and 8.9 and >1.6 in males and >8.7 and >1.6 in females, respectively. The TyG index’s area under the curve was higher than that of the HOMA-IR in both sexes. MONWs distinguished by the cut-off values of the TyG index and HOMA-IR were 2.370 and 1.726 for males and 2.249 and 1.710 for females times more likely to develop diabetes. Conclusions: The TyG index showed a stronger association with diabetes in Korean individuals without underweight or obesity than the HOMA-IR.
Kim et al. (Thu,) conducted a cross-sectional in Diabetes (n=10,471). TyG index vs. HOMA-IR was evaluated on Diabetes (2.370 (males) and 2.249 (females) times more likely). The TyG index showed a stronger association with diabetes than HOMA-IR in normal-weight individuals, increasing the likelihood of diabetes by 2.37 times in males and 2.25 times in females.