Key result
Atrial fibrillation treatment strategies, including the Atrial Fibrillation Better Care pathway, may influence the trajectory of cognitive decline, though further prospective studies are required.
Why the study?
Atrial fibrillation is associated with a heightened risk of dementia, but the underlying mechanisms and the impact of existing treatment strategies on cognitive decline remain unclear.
How do atrial fibrillation treatment strategies impact cognitive function and the risk of dementia?
How do atrial fibrillation treatment strategies impact cognitive function and the risk of dementia?
This review highlights the potential impact of atrial fibrillation management strategies on cognitive trajectory and emphasizes the need for prospective studies to develop dementia prevention strategies in AF patients.
AF may warrant cognitive vigilance in patients; leaves open mechanistic targets and whether intervention alters outcomes.
There is increasing evidence to suggest that atrial fibrillation is associated with a heightened risk of dementia. The mechanism of interaction is unclear. Atrial fibrillation-induced cerebral infarcts, hypoperfusion, systemic inflammation, and anticoagulant therapy-induced cerebral microbleeds, have been proposed to explain the link between these conditions. An understanding of the pathogenesis of atrial fibrillation-associated cognitive decline may enable the development of treatment strategies targeted towards the prevention of dementia in atrial fibrillation patients. The aim of this review is to explore the impact that existing atrial fibrillation treatment strategies may have on cognition and the putative mechanisms linking the two conditions. This review examines how components of the 'Atrial Fibrillation Better Care pathway' (stroke risk reduction, rhythm control, rate control, and risk factor management) may influence the trajectory of atrial fibrillation-associated cognitive decline. The requirements for further prospective studies to understand the mechanistic link between atrial fibrillation and dementia and to develop treatment strategies targeted towards the prevention of atrial fibrillation-associated cognitive decline, are highlighted.
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Bodagh et al. (2023) conducted a review in Atrial fibrillation. Atrial fibrillation treatment strategies was evaluated on Cognitive decline and dementia. Atrial fibrillation treatment strategies, including the Atrial Fibrillation Better Care pathway, may influence the trajectory of cognitive decline, though further prospective studies are required.
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