Key result
Left ventricular diastolic dysfunction in hemodialysis patients was positively correlated with serum total antioxidant capacity and aortic calcification score, independent of degenerative aortic stenosis.
Why the study?
CKD induces myocardial changes influencing morbidity and mortality, prompting investigation into whether left ventricular diastolic dysfunction correlates with inflammatory, oxidative, metabolic, nutritional, and atherosclerotic status in chronic hemodialysis patients.
Does inflammatory, oxidative, and atherosclerotic status correlate with left ventricular diastolic dysfunction in hemodialysis patients?
Observational (n=51)
No
Does inflammatory, oxidative, and atherosclerotic status correlate with left ventricular diastolic dysfunction in hemodialysis patients?
In hemodialysis patients, left ventricular diastolic dysfunction is significantly associated with markers of oxidative stress and aortic calcification, independent of degenerative aortic stenosis.
Answers are grounded in this paper and cite their sources.
May link inflammatory and metabolic factors to diastolic dysfunction in hemodialysis; leaves open whether targeting them alters outcomes.
Introduction: Chronic kidney disease (CKD) induces changes in the myocardium known to influence morbidity and mortality, most severe in patients with end stage renal disease. Objectives: The working hypothesis was that in patients on chronic hemodialysis the prevalence of left ventricular diastolic dysfunction is correlated with the inflammatory, oxidative, metabolic, nutritional, and atherosclerotic status. Patients and Methods: An observational study was performed on 51 patients (age 59.76 ± 13.24 years) on hemodialysis treatment. Transthoracic cardiac ultrasound was conducted to evaluate LVDD. The burden of cardiac and arterial atherosclerosis was evaluated by cardiac ultrasound (aortic and mitral valve calcifications), vascular ultrasound (carotid and femoral atheroma plaques, common carotid intima-media thickness), and by abdominal radiography (aortic calcification score). Demographic and anthropometric parameters were determined. Blood samples were used to determine laboratory parameters reflecting the inflammatory, oxidative, and metabolic/nutrition status. Results: LVDD is positively correlated with the serum level of C-reactive protein (CRP) (P=0.04), the total antioxidant capacity of the serum (P=0.04), the presence (P=0.022) and number (P=0.04) of femoral plaques, the aortic calcification score (P=0.02), aortic valve stenosis (P=0.037), aortic annulus calcifications (P=0.02) and mitral valve calcifications (P=0.041). After the removal of the main confounder, degenerative aortic stenosis, only the associations with serum total antioxidant capacity (P=0.04) and aortic calcification score (P= 0.02) maintain their statistical significance. Conclusion: LVDD is positively correlated with inflammation and oxidative stress markers and with the severity of aortic calcification.
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Dragoș et al. (2022) conducted an observational in End-stage renal disease on hemodialysis (n=51). Inflammation, oxidative stress, and atherosclerosis markers vs. Lower levels or absence of markers was evaluated on Presence of left ventricular diastolic dysfunction. Left ventricular diastolic dysfunction in hemodialysis patients was positively correlated with serum total antioxidant capacity and aortic calcification score, independent of degenerative aortic stenosis.
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