Key result
Higher atherogenic index of plasma is independently associated with increased epicardial adipose tissue volume (≥ 52.3 cm3) after adjusting for traditional risk factors and coronary plaque burden (OR 3.581).
Why the study?
The atherogenic index of plasma is a novel biomarker of atherogenic dyslipidaemia, but its relationship with cardiac adipose tissue depots is unknown.
Does atherogenic dyslipidaemia (measured by atherogenic index of plasma) associate with adverse cardiac adipose tissue changes on coronary computed tomography angiography?
Cross-Sectional (n=161)
Yes
Does atherogenic dyslipidaemia (measured by atherogenic index of plasma) associate with adverse cardiac adipose tissue changes on coronary computed tomography angiography?
Odds Ratio: 3.581 (95% CI 1.084–11.827)
p-value: p=0.036
The atherogenic index of plasma is independently associated with increased epicardial adipose tissue volume, suggesting a link between atherogenic dyslipidemia and adverse cardiac adipose tissue changes.
AIP association with cardiac adipose tissue on CCTA is hypothesis-generating; leaves open whether it improves risk stratification or warrants targeted therapy.
The atherogenic index of plasma (AIP) is a novel biomarker of atherogenic dyslipidaemia (AD), but its relationship with cardiac adipose tissue depots is unknown. We aimed to assess the association of AD with cardiac adipose tissue parameters on coronary computed tomography angiography (CCTA). We studied 161 patients who underwent CCTA between 2008 and 2011 (age 59.0 ± 14.0 years). AD was defined as triglyceride (TG) > 1.7 mmol/L and HDL < 1.0 mmol/L (n = 34). AIP was defined as the base 10 logarithmic ratio of TG to HDL. Plaque burden was assessed using the CT-Leaman score (CT-LeSc). We studied volume and attenuation of epicardial adipose tissue (EAT-v and EAT-a) and pericoronary adipose tissue (PCAT-v and PCAT-a) on CCTA using semi-automated software. Patients with AD had higher PCAT-v (p = 0.042) and EAT-v (p = 0.041). AIP was associated with EAT-v (p = 0.006), type II diabetes (p = 0.009) and male sex (p < 0.001) and correlated with CT-LeSc (p = 0.040). On multivariable analysis, AIP was associated with EAT-v ≥ 52.3 cm 3 , age, male sex and type II diabetes when corrected for traditional risk factors and plaque burden. AIP is associated with increased EAT volume, but not PCAT-a, after multivariable adjustment. These findings indicate AIP is associated with adverse adipose tissue changes which may increase coronary risk.
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Yuvaraj et al. (2022) conducted a cross-sectional in Suspected coronary artery disease (n=161). Atherogenic index of plasma (AIP) vs. Lower AIP was evaluated on High epicardial adipose tissue volume (EAT-v ≥ 52.3 cm3) (OR 3.581, 95% CI 1.084-11.827, p=0.036). Higher atherogenic index of plasma is independently associated with increased epicardial adipose tissue volume (≥ 52.3 cm3) after adjusting for traditional risk factors and coronary plaque burden (OR 3.581).
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