Key result
Patients with less severe heart failure (NYHA Class 1-2) had significantly better Letter-Number Sequencing scores compared to those with more severe heart failure (NYHA Class 3-4) (β 0.47).
Why the study?
Congestive heart failure has been linked to dementia for reasons not well understood, prompting investigation into whether specific measures of CHF severity are associated with cognitive performance or cerebral blood flow velocity.
Comparison
CHF characteristics including NYHA classification, CHF type, and LVEF
Design
Retrospective cohort study
Authors
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NYHA class and select LVEF categories show limited links to cognition or CBFV; hypothesis-generating for perfusion mechanisms, larger controlled studies needed.
Cohort (n=138)
No
Mean Difference: 0.47 (95% CI 0.09–0.84)
In outpatients with decompensated heart failure, less severe NYHA class is associated with better attention and processing speed, and mildly reduced LVEF is associated with higher internal carotid artery blood flow velocity compared to severely reduced LVEF.
Kong et al. (2025) conducted a cohort in Congestive heart failure (n=138). NYHA Class 1-2 vs. NYHA Class 3-4 was evaluated on Letter-Number Sequencing (LNS) score (β 0.47, 95% CI 0.09, 0.84). Patients with less severe heart failure (NYHA Class 1-2) had significantly better Letter-Number Sequencing scores compared to those with more severe heart failure (NYHA Class 3-4) (β 0.47).
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