Key result
Thrombin-induced DNA synthesis in rat aortic smooth muscle cells was completely blocked by anti-IGF I antiserum and antisense oligonucleotides, demonstrating that the IGF I receptor pathway is essential for thrombin-induced mitogenesis.
p-value: p=<0.025
A functional IGF I-IGF I receptor pathway is essential for thrombin-induced mitogenic signaling in vascular smooth muscle cells, demonstrating cross-talk between G-protein coupled and tyrosine kinase receptors.
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No immediate clinical implications; leaves open IGF-I mediation of thrombin effects in vascular disease.
Delafontaine et al. (1996) studied Thrombin-induced mitogenesis. Thrombin and anti-IGF I antiserum / antisense oligonucleotides vs. Control (serum-free medium) was evaluated on DNA synthesis ([3H]thymidine incorporation) (p=<0.025). Thrombin-induced DNA synthesis in rat aortic smooth muscle cells was completely blocked by anti-IGF I antiserum and antisense oligonucleotides, demonstrating that the IGF I receptor pathway is essential for thrombin-induced mitogenesis.
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