Population
Cultured rat aortic smooth muscle cells (RASM)
Comparison
Exposure to serum or platelet-derived growth… vs Quiescent cells (serum-deprived for 48 hours)
Design
Preclinical
Follow-up
24 hours
Authors
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Should not alter hypertension management; hypothesis-generating for PDGF-IGF-I regulation of vascular smooth muscle growth.
Regulation of IGF I expression by competence growth factors such as PDGF may play an important role in the control of vascular smooth muscle cell growth.
Delafontaine et al. (1991) studied this question.
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