Population
Rat aortic smooth muscle cells (RASMs)
Comparison
Exposure to growth factors and phorbol esters vs Untreated quiescent RASMs or serum-deprived cells
Design
Preclinical
Follow-up
Up to 48 hours
Authors
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May inform studies of vascular remodeling; leaves open clinical relevance of IGF-I receptor modulation pending in vivo validation.
Growth factors like PDGF and FGF upregulate IGF I receptors on vascular smooth muscle cells via a protein kinase C-dependent pathway, which may play a role in vascular proliferative responses.
Ververis et al. (1993) studied this question.
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