July 1, 1995Journal of Cellular Physiology

Regulation of insulin‐like growth factor (IGF) binding protein‐2 synthesis and degradation by platelet‐derived growth factor and the IGFs is enhanced by serum deprivation in vascular smooth muscle cells

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Population

Porcine vascular smooth muscle cells (SMC) in vitro

Comparison

Exposure to platelet-derived growth factor… vs Control conditions

Design

Preclinical

Follow-up

24 to 72 hours

Authors

WCWendie S. CohickRutgers, The State University of New Jersey AGA GockermanUniversity of North Carolina at Chapel Hill DCDavid R. ClemmonsNorthwestern University

Discussion

Member takes

Implication

Hypothesis-generating for IGFBP-2 regulation in vascular smooth muscle; does not yet inform human cardiovascular therapies.

Structured PICO

Population

Porcine vascular smooth muscle cells (SMC) in vitro

Intervention

Exposure to platelet-derived growth factor (PDGF) (20 ng/ml), insulin (5 micrograms/ml), IGF-I, IGF-II, FGF, TGF-beta, or EGF for 24 to 72 hours, with or without prior serum deprivation

Comparator

Control conditions (e.g., without prior serum deprivation or untreated cells)

Outcome

Levels of IGFBP-2 and IGFBP-4 protein in conditioned media and mRNA levelssurrogate

In porcine vascular smooth muscle cells, PDGF and insulin stimulate the synthesis of IGFBP-2 and IGFBP-4, whereas IGFs promote their post-translational degradation.

Cite This Study

Cohick et al. (1995) studied this question.

synapsesocial.com/papers/6a95d3516823ee7bfe514551 https://doi.org/10.1002/jcp.1041640123

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Regulation of insulin‐like growth factor (IGF) binding protein‐2 synthesis and degradation by platelet‐derived growth factor and the IGFs is enhanced by serum deprivation in vascular smooth muscle cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Regulation of insulin‐like growth factor (IGF) binding protein‐2 synthesis and degradation by platelet‐derived growth factor and the IGFs is enhanced by serum deprivation in vascular smooth muscle cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider