February 1, 1992Endocrinology

Insulin-like growth factors (IGFs) reduce IGF-binding protein-4 (IGFBP-4) concentration and stimulate IGFBP-3 independently of IGF receptors in human fibroblasts and epidermal cells.

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Population

Adult human fibroblast cell line N3652 and human epidermal squamous cell carcinoma line SCL-1

Comparison

IGF-I, IGF-II, insulin, type 1 IGF receptor… vs Basal levels (no peptide addition)

Design

Preclinical

Follow-up

72 hours

Authors

Discussion

May indicate IGFBP regulation beyond IGF1R in fibroblasts; leaves open in vivo relevance and clinical translation.

Population

Adult human fibroblast cell line N3652 and human epidermal squamous cell carcinoma line SCL-1

Intervention

IGF-I, IGF-II, insulin, type 1 IGF receptor antibody alpha IR-3, or [Leu27]IGF-II added to serum-free medium

Comparator

Basal levels (no peptide addition)

Outcome

Concentrations of IGFBP-3 and IGFBP-4 in conditioned mediumsurrogate

IGF-I and IGF-II regulate IGFBP-3 and IGFBP-4 concentrations in human fibroblasts and epidermal cells independently of the type 1 IGF receptor.

Neely et al. (1992) studied this question.

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