Population
Rat H4IIE hepatoma cells stabilized in serum-free medium
Comparison
Insulin, 8-cAMP, dexamethasone, rat GH… vs Control (untreated cells in serum-free medium)
Design
Preclinical
Follow-up
up to 24 hours
Authors
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Insulin downregulation of IGFBP-1 in rat hepatoma cells is hypothesis-generating; leaves open translation to human IGF-I regulation and metabolic disease.
Insulin plays a dominant role in downregulating IGFBP-1 production and mRNA abundance in rat hepatoma cells, counteracting the stimulatory effects of cAMP and dexamethasone.
Unterman et al. (1991) studied this question.
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