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August 1, 1990Molecular EndocrinologyOpen Access

Transcriptional Regulation of Rat Insulin-Like Growth Factor-Binding Protein-1 Expression by Growth Hormone

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Population

Hypophysectomized rats (GH-deficient rats)

Comparison

Growth hormone administration vs Sham-operated control rats

Design

Preclinical

Follow-up

Up to 8 days

Authors

CSCharita SeneviratneJLJiangming LuoLMLiam J. Murphy

Discussion

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Overview

Challenges prior view of GH-independent IGFBP-1 regulation in rats; leaves open relevance to human GH-IGF physiology.

Structured PICO

P
Population
Hypophysectomized rats (GH-deficient rats)
I
Intervention
Growth hormone (GH) administration (single ip injection or chronic treatment for 8 days)
C
Comparator
Sham-operated control rats
O
Outcome
Hepatic IGFBP-1 expression (transcription rate and mRNA abundance)surrogate

This study demonstrates that hepatic IGFBP-1 expression is inversely regulated by growth hormone in rats, challenging the previous notion that it is GH-independent.

Cite This Study

Seneviratne et al. (1990) studied this question.

synapsesocial.com/papers/6a700df6a7fbea1e4407ee2ahttps://doi.org/10.1210/mend-4-8-1199
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