Key result
Laser Doppler flowmetry provides a non-invasive method to assess microvascular endothelial dysfunction in chronic kidney disease, though larger studies are needed to establish its predictive value.
Answers are grounded in this paper and cite their sources.
Laser Doppler flowmetry is a promising non-invasive tool for early detection of endothelial dysfunction in CKD, though further standardization and large-scale validation are needed.
Cardiovascular diseases are the major causes of mortality in patients with chronic kidney disease (CKD). The complex process of accelerated athero- and arteriosclerosis in CKD is associated with this phenomenon, where endothelial dysfunction (ED) is one of the initial steps. Hence, the early diagnosis of ED can potentially lead to early interventions which could result in a better outcome for these patients. Several methodologies have been developed for the diagnosis of ED. Laser Doppler flowmetry (LDF) enables us to study the microcirculation continuously in a non-invasive manner. In our review we would like to focus on different tests developed for LDF, like postocclusive reactive hyperaemia, local heating, iontophoresis, microdialysis or analysis of flowmotion. We would also like to summarize the available data in CKD with these methodologies to enlighten their perspectives in the clinical use on this patient population.
No takes yet. Share an insight, caveat, or question.
Levente Babos (2013) conducted a review in Chronic kidney disease. Laser Doppler flowmetry was evaluated. Laser Doppler flowmetry provides a non-invasive method to assess microvascular endothelial dysfunction in chronic kidney disease, though larger studies are needed to establish its predictive value.
Synapse has enriched 10 related papers. Consider them for comparative context: