Resistance to stretch at low pressures in human iliac arteries is almost entirely due to elastin fibers, while at high pressures it is almost entirely due to collagenous fibers.
The non-linear distensibility of arteries is driven by elastin fibers at low pressures and collagen fibers at physiological and high pressures.
It is characteristic of arteries that they do not obey Hooke's law, but resist further stretch more strongly, the more they are stretched. It appears that this might be due to the combination of elastin fibers in the elastic laminae, with the much less distensible collagenous libers in the media and adventitia, more and more of which reach their 'unstretched length' as distension is increased. This has been verified on human iliac arteries, from autopsy, by comparing the 'elastic diagrams' (tension vs. circumference) before and after differential digestion of collagen by formic acid, and digestion of elastin by crude trypsin (containing an elastase). This proved that the resistance to stretch at low pressures was almost entirely due to elastin fibers, that at physiological pressures due to both collagenous and elastin fibers, but dominantly to collagen, and that at high pressures almost entirely due to collagenous fibers. In future work on the effect of age on the elasticity of iliac arteries, the initial slope of the elastic diagram can be taken as an index of the state, or number, of the elastin fibers, and the final slope as an index of the state, or number, of collagenous fibers.
Roach et al. (Thu,) conducted a other in Human iliac arteries from autopsy. Differential digestion of collagen and elastin vs. Before digestion was evaluated on Elastic diagrams (tension vs. circumference). Resistance to stretch at low pressures in human iliac arteries is almost entirely due to elastin fibers, while at high pressures it is almost entirely due to collagenous fibers.