Key result
ROTEM® platelet analysis successfully detected aspirin treatment but inadequately detected clopidogrel compared to light transmission aggregometry.
Why the study?
Patients undergoing CABG or CEA continue perioperative antiplatelet therapy, which may increase bleeding risk, creating a need to evaluate ROTEM platelet for detecting antiplatelet therapy and predicting bleeding.
Does ROTEM® platelet accurately detect antiplatelet therapy and predict bleeding risk in patients undergoing CABG or CEA?
Population
20 CABG patients continuing aspirin and 20 CEA patients continuing clopidogrel or clopidogrel plus aspirin
Comparison
ROTEM platelet vs light transmission aggregometry (LTA)
Design
Observational cohort study
Authors
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ROTEM platelet testing may identify antiplatelet effects perioperatively; leaves open utility for bleeding risk prediction or desmopressin guidance.
Observational (n=40)
Does ROTEM® platelet accurately detect antiplatelet therapy and predict bleeding risk in patients undergoing CABG or CEA?
ROTEM® platelet can detect aspirin but not clopidogrel treatment in surgical patients, and ex vivo desmopressin does not improve platelet function in this setting.
Schultz-Lebahn et al. (2021) conducted an observational in Patients undergoing CABG or CEA on antiplatelet therapy (n=40). ROTEM® platelet analysis vs. Light transmission aggregometry (LTA) was evaluated on Detection of antiplatelet therapy and association with bleeding. ROTEM® platelet analysis successfully detected aspirin treatment but inadequately detected clopidogrel compared to light transmission aggregometry.
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