Key result
Ivabradine induced a marked concentration and use-dependent inhibition of the pacemaker current I(f) in human atrial myocytes with an IC50 of 2.9 microM.
Why the study?
Does ivabradine inhibit the pacemaker current I(f) in human atrial myocytes?
Does ivabradine inhibit the pacemaker current I(f) in human atrial myocytes?
Effect estimate: IC50 2.9 microM
Ivabradine inhibits the I(f) current in human atrial myocytes, suggesting a potential mechanism for protecting against atrial arrhythmias.
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May influence atrial ectopy; leaves open clinical relevance for arrhythmia management.
Chemaly et al. (2007) studied Patients undergoing cardiac surgery. Ivabradine was evaluated on I(f) inhibition (IC50 2.9 microM). Ivabradine induced a marked concentration and use-dependent inhibition of the pacemaker current I(f) in human atrial myocytes with an IC50 of 2.9 microM.
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