Key result
In rabbit isolated sino-atrial node cells, 2 mM caesium caused a 30% reduction in the rate of beating, indicating that the hyperpolarization-activated current if normally contributes to pacemaking.
Why the study?
Does caesium block of the hyperpolarization-activated current (if) arrest spontaneous pacemaking in rabbit isolated sino-atrial node cells?
Population
Rabbit isolated sino-atrial (SA) node cells
Comparison
1 and 2 mM caesium to block the… vs Control (unblocked state)
Design
Preclinical
Authors
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Cs+ fully blocks If in rabbit SA node cells; leaves open its contribution to human pacemaker activity.
Does caesium block of the hyperpolarization-activated current (if) arrest spontaneous pacemaking in rabbit isolated sino-atrial node cells?
The hyperpolarization-activated current (if) makes an important contribution to pacemaker depolarization in SA node cells, but its complete block by caesium slows rather than arrests pacemaking, suggesting the presence of a background inward current.
Denyer et al. (1990) studied Rabbit isolated sino-atrial node cells. Caesium (Cs+) vs. Control was evaluated on Spontaneous pacemaker activity / rate of beating. In rabbit isolated sino-atrial node cells, 2 mM caesium caused a 30% reduction in the rate of beating, indicating that the hyperpolarization-activated current if normally contributes to pacemaking.
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