Key result
Epilepsy and febrile convulsions were associated with significantly higher heart rates (129.64 and 125.79 vs 108.78) and increased QT dispersion compared to healthy controls (p<0.001).
Why the study?
Epilepsy and febrile convulsion are common neurological diseases with a significant effect on cardiac functions, prompting evaluation of ECG parameter alterations compared with controls.
Do electrocardiography parameters differ in children with epilepsy or febrile convulsion compared to healthy controls?
Case-Control (n=270)
No
Do electrocardiography parameters differ in children with epilepsy or febrile convulsion compared to healthy controls?
Absolute Event Rate: 129.64% vs 108.78%
p-value: p=<0.001
Children with epilepsy and febrile convulsions exhibit significant alterations in ECG parameters, including increased heart rate and QT/QTc dispersion, compared to healthy controls.
Potential ECG changes in pediatric epilepsy or febrile convulsions merit attention; leaves open whether they influence management or outcomes.
Epilepsy and febrile convulsion are the most common neurological diseases with significant effect on cardiac functions. This study aimed to evaluate electrocardiography parameters alterations in epilepsy and febrile convulsion children compared with controls. In this comparison study, 270 children analyzed who shared equally in epilepsy, febrile convulsion, and healthy that aged from 0.5 to 5 years. The participants were collected from Ali ibn Abi Talib Hospital of Zahedan, Iran. Epilepsy confirmed based on definition of having at least two unprovoked seizures in 24 hours. Febrile convulsion was confirmed based on its definition by the International League against Epilepsy. Healthy children selected from those referred to the hospital with fever and without any underline diseases. Electrocardiography was performed by a pediatric cardiologist. Data were analyzed using SPSS 19 with p < 0.05 significant level. Heart rate was higher in epilepsy (129.64 ± 27.63) compared with control (108.78 ± 26.01) and febrile convulsion (125.79 ± 25.38; X 2 = 28.701, p < 0.001). S wave in lead V1 was higher in controls (0.72 ± 0.36) compared with epilepsy (0.58 ± 0.45) and febrile convulsion (0.58 ± 0.36). QT dispersion and QTc dispersion levels were higher in epilepsy than febrile convulsion children that both were higher than controls. Concluded that R in aVL, LV mass (LVM), QT dispersion, and QTc dispersion were higher significantly in epilepsy compared with febrile convulsion children. To maintain a good strategic treatment in patients with epilepsy and febrile convulsion, there is a need to assess alternations in ECG parameters, especially QT interval changes that lead to better comprehensive autonomic changes.
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Noori et al. (2020) conducted a case-control in Epilepsy and febrile convulsion (n=270). Epilepsy and febrile convulsion vs. Healthy controls was evaluated on Heart rate (p=<0.001). Epilepsy and febrile convulsions were associated with significantly higher heart rates (129.64 and 125.79 vs 108.78) and increased QT dispersion compared to healthy controls (p<0.001).
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