Key result
Sudden unexpected death in epilepsy (SUDEP) was associated with a significantly higher prevalence of myocardial fibrosis compared to controls (40% vs 6.6%, P=0.03).
Why the study?
Is sudden unexpected death in epilepsy (SUDEP) associated with increased myocardial fibrosis compared to controls?
Population
44 subjects from Northern Jutland, Denmark. Histologic evaluation was possible in 15 SUDEP cases and 15…
Comparison
Sudden unexpected death in epilepsy (SUDEP) vs Controls (non-SUDEP deaths)
Design
Case-control
Authors
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Should not yet inform SUDEP risk assessment; leaves open myocardial fibrosis as a hypothesis-generating target.
Case-Control (n=44)
Is sudden unexpected death in epilepsy (SUDEP) associated with increased myocardial fibrosis compared to controls?
Absolute Event Rate: 40% vs 6.6%
p-value: p=0.03
SUDEP is associated with significant deep and subendocardial myocardial fibrosis, suggesting that repetitive epileptic seizures may cause myocardial ischemia leading to lethal arrhythmias.
P-Codrea et al. (2005) conducted a case-control in Sudden unexpected death in epilepsy (SUDEP) (n=44). Sudden unexpected death in epilepsy (SUDEP) vs. Controls was evaluated on Several foci of fibrotic changes in the deep and subendocardial myocardium (p=0.03). Sudden unexpected death in epilepsy (SUDEP) was associated with a significantly higher prevalence of myocardial fibrosis compared to controls (40% vs 6.6%, P=0.03).
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