Key result
Cardiac biomarkers, particularly high-sensitivity troponin, are essential tools in the emergency department for the rapid diagnosis, risk stratification, and safe early discharge of patients with chest pain.
Why the study?
This review aims to summarize current knowledge and recent progress in cardiac biomarker discovery, from routine emergency room use to prognostic roles in risk assessment tools.
This review highlights the critical role of high-sensitivity cardiac troponins and accelerated diagnostic algorithms in the modern emergency management of suspected acute coronary syndromes.
Cardiac peptides may inform ACS prognosis per class IIa guidance; leaves open optimal thresholds and timing in emergency settings.
The role of cardiac biomarkers in diagnosing acute myocardial infarction is undoubted. In the 2020 guidelines of the European Society of Cardiology, the measurement of cardiac peptides to gain prognostic information has a class IIa indication in all patients with ACS. In emergency care, ruling out a non-ST elevation myocardial infarction requires documentation of normal levels of cardiac biomarkers, which remain stable or have very small variations within several hours. This review aims to summarize the current knowledge and recent progresses in the field of cardiac biomarker discovery, from their routine use in emergency rooms to their prognostic roles in modern risk assessment tools. Integrated approaches combining cardiac troponin with other biomarkers of ventricular dysfunction or inflammation, or with modern cardiac imaging in emergency care are also presented, as well as the role of modern algorithms for serial troponin measurement in the modern management of emergency departments.
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Benedek et al. (2022) conducted a review in Acute coronary syndromes and chest pain. Cardiac biomarkers (e.g., high-sensitivity troponin) was evaluated. Cardiac biomarkers, particularly high-sensitivity troponin, are essential tools in the emergency department for the rapid diagnosis, risk stratification, and safe early discharge of patients with chest pain.
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