Key result
Nifedipine and TMB-8 each produced dose-dependent inhibition of up to 50% of the maximum renal vasoconstriction produced by ANG II, with additive effects indicating distinct calcium pathways.
Population
Anesthetized euvolemic Wistar-Kyoto rats pretreated with indomethacin
Comparison
Coadministration of nifedipine, TMB-8, or… vs ANG II or BAY K 8644 alone
Design
Preclinical
Authors
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Should not change hypertension management; leaves open whether calcium signaling targets translate beyond rodent models.
In vivo ANG II-induced renal vasoconstriction is mediated equally by voltage-dependent L-type calcium channels and IP3-mediated intracellular calcium mobilization.
Ruan et al. (1996) studied ANG II-induced renal vasoconstriction. Nifedipine, TMB-8, or heparin vs. ANG II alone was evaluated on Maximum renal vasoconstriction (decrease in renal blood flow). Nifedipine and TMB-8 each produced dose-dependent inhibition of up to 50% of the maximum renal vasoconstriction produced by ANG II, with additive effects indicating distinct calcium pathways.
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