Cyclophilin A in Arrhythmogenic Cardiomyopathy Cardiac Remodeling

Figures

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  Figure 1. Representative cyclophilin A (CyPA) immunostaining of healthy control (HC) (a) and arrhythmogenic cardiomyopathy (ACM) patient (b) right ventricle (RV) sections. Positive signal stained brown. Quantification of CyPA expression level in HC and ACM RV tissues (c). ** p value ≤ 0.01 at Student’s T test.

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  Figure 2. Quantification of fatty substitution area in HC and ACM RV sections (a). Correlation between CyPA expression levels and the extent of fatty substitution (b). * p value ≤ 0.05 at Student’s T test.

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  Figure 3. Immunofluorescence staining of ACM RV section (a). Particular of a preadipocyte, positive for CD29 and perilipin 1 (PLIN1), expressing cyclophilin A (CyPA) (b). The image of merged signals is also shown.

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  Figure 4. CyPA gene expression levels in HC- and ACM-derived cardiac mesenchymal stromal cells (C-MSC) cultured in adipogenic condition. * p value ≤ 0.05 at two-way ANOVA and ° p value ≤ 0.05 at Bonferroni post-test.

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  Figure 5. CyPA protein expression levels in cell lysates (a) and supernatants (b) of HC and ACM C-MSC cultured in adipogenic condition for 72 h. *** p value ≤ 0.001 at two-way ANOVA and § p value ≤ 0.05 vs. “24 h”, # p value ≤ 0.05 vs. “0”, ### p value ≤ 0.001 vs. “0” at Bonferroni post-test. °° p value ≤ 0.01 at Friedman test, and ç p value ≤ 0.05 vs. “0” at Dunn’s Multiple Comparison post-test.