What question did this study set out to answer?

To clarify the functional distinction between pannexin channels and gap junction hemichannels.

May 1, 2011ChannelsOpen Access

Pannexin channels are not gap junction hemichannels

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This investigation clarifies the functional role of pannexins in membranes, suggesting revised terminology in molecular biology.

To clarify the functional distinction between pannexin channels and gap junction hemichannels.
Literature review of pannexin and connexin channel properties.
Analysis of molecular topology and pharmacological sensitivity comparisons between pannexins and connexins.
Argumentative case presentation against the use of 'hemichannels' for pannexins.
Pannexins function as channels in single membranes, not as intercellular channels.
Pannexins should be referred to as channels rather than hemichannels due to their distinct roles.
The current literature's use of 'hemichannels' for pannexins is misleading.

Sosinsky et al. (2011) studied this question.

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